Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis.
Identifieur interne : 007154 ( Main/Exploration ); précédent : 007153; suivant : 007155Plasma vascular endothelial growth Factor-A (VEGF-A) and VEGF-A gene polymorphism are associated with hydrocele development in lymphatic filariasis.
Auteurs : Alexander Yaw Debrah [Allemagne] ; Sabine Mand ; Mohammad Reza Toliat ; Yeboah Marfo-Debrekyei ; Linda Batsa ; Peter Nürnberg ; Bernard Lawson ; Ohene Adjei ; Achim Hoerauf ; Kenneth PfarrSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2007.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Facteur de croissance endothéliale vasculaire de type A (génétique), Facteur de croissance endothéliale vasculaire de type A (sang), Femelle, Filariose lymphatique (), Filariose lymphatique (génétique), Filariose lymphatique (parasitologie), Filariose lymphatique (sang), Haplotypes (génétique), Humains, Hydrocèle (génétique), Hydrocèle (sang), Hydrocèle (étiologie), Mâle, Polymorphisme de nucléotide simple, Wuchereria bancrofti (croissance et développement).
- MESH :
- croissance et développement : Wuchereria bancrofti.
- génétique : Facteur de croissance endothéliale vasculaire de type A, Filariose lymphatique, Haplotypes, Hydrocèle.
- parasitologie : Filariose lymphatique.
- sang : Facteur de croissance endothéliale vasculaire de type A, Filariose lymphatique, Hydrocèle.
- étiologie : Hydrocèle.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Femelle, Filariose lymphatique, Humains, Mâle, Polymorphisme de nucléotide simple.
English descriptors
- KwdEn :
- Adolescent, Adult, Animals, Elephantiasis, Filarial (blood), Elephantiasis, Filarial (complications), Elephantiasis, Filarial (genetics), Elephantiasis, Filarial (parasitology), Female, Haplotypes (genetics), Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Testicular Hydrocele (blood), Testicular Hydrocele (etiology), Testicular Hydrocele (genetics), Vascular Endothelial Growth Factor A (blood), Vascular Endothelial Growth Factor A (genetics), Wuchereria bancrofti (growth & development).
- MESH :
- chemical , blood : Vascular Endothelial Growth Factor A.
- blood : Elephantiasis, Filarial, Testicular Hydrocele.
- complications : Elephantiasis, Filarial.
- etiology : Testicular Hydrocele.
- genetics : Elephantiasis, Filarial, Haplotypes, Testicular Hydrocele, Vascular Endothelial Growth Factor A.
- growth & development : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Adolescent, Adult, Animals, Female, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
Hydrocele is a build-up of fluid in the scrotal regions of a proportion of men infected with the filarial nematode Wuchereria bancrofti. Vascular endothelial growth factors (VEGF) are major mediators of vascular permeability and angiogenesis in the development and progression of many diseases, making them candidates in hydrocele development. We assessed the role of VEGF-A genetic polymorphisms in hydrocele development in a cohort of lymphatic filariasis patients from Ghana. Three VEGF-A promoter polymorphisms were examined. The C/C genotype at -460 was significantly higher in hydrocele patients ([P = 0.0007], OR = 3.8 [95% CI = 1.9-8.2]) than in non-hydrocele patients. Furthermore, plasma levels of VEGF-A were significantly higher in subjects with the C/C genotype than in those with other genotypes. Also, a positive correlation (R(2) = 0.412, P = 0.026) was observed between plasma VEGF-A and stage of hydrocele. The data suggest that the C polymorphism at -460 is a genetic risk factor for hydrocele development in lymphatic filariasis.
PubMed: 17978056
Affiliations:
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(genetics)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Female</term><term>Haplotypes (genetics)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Testicular Hydrocele (blood)</term><term>Testicular Hydrocele (etiology)</term><term>Testicular Hydrocele (genetics)</term><term>Vascular Endothelial Growth Factor A (blood)</term><term>Vascular Endothelial Growth Factor A (genetics)</term><term>Wuchereria bancrofti (growth & development)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Facteur de croissance endothéliale vasculaire de type A (génétique)</term><term>Facteur de croissance endothéliale vasculaire de type A (sang)</term><term>Femelle</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (génétique)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (sang)</term><term>Haplotypes (génétique)</term><term>Humains</term><term>Hydrocèle (génétique)</term><term>Hydrocèle (sang)</term><term>Hydrocèle (étiologie)</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term><term>Wuchereria bancrofti (croissance et développement)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Testicular Hydrocele</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Testicular Hydrocele</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Elephantiasis, 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xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Animals</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Femelle</term><term>Filariose lymphatique</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hydrocele is a build-up of fluid in the scrotal regions of a proportion of men infected with the filarial nematode Wuchereria bancrofti. Vascular endothelial growth factors (VEGF) are major mediators of vascular permeability and angiogenesis in the development and progression of many diseases, making them candidates in hydrocele development. We assessed the role of VEGF-A genetic polymorphisms in hydrocele development in a cohort of lymphatic filariasis patients from Ghana. Three VEGF-A promoter polymorphisms were examined. The C/C genotype at -460 was significantly higher in hydrocele patients ([P = 0.0007], OR = 3.8 [95% CI = 1.9-8.2]) than in non-hydrocele patients. Furthermore, plasma levels of VEGF-A were significantly higher in subjects with the C/C genotype than in those with other genotypes. Also, a positive correlation (R(2) = 0.412, P = 0.026) was observed between plasma VEGF-A and stage of hydrocele. The data suggest that the C polymorphism at -460 is a genetic risk factor for hydrocele development in lymphatic filariasis.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Bonn</li></settlement></list><tree><noCountry><name sortKey="Adjei, Ohene" sort="Adjei, Ohene" uniqKey="Adjei O" first="Ohene" last="Adjei">Ohene Adjei</name><name sortKey="Batsa, Linda" sort="Batsa, Linda" uniqKey="Batsa L" first="Linda" last="Batsa">Linda Batsa</name><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><name sortKey="Lawson, Bernard" sort="Lawson, Bernard" uniqKey="Lawson B" first="Bernard" last="Lawson">Bernard Lawson</name><name sortKey="Mand, Sabine" sort="Mand, Sabine" uniqKey="Mand S" first="Sabine" last="Mand">Sabine Mand</name><name sortKey="Marfo Debrekyei, Yeboah" sort="Marfo Debrekyei, Yeboah" uniqKey="Marfo Debrekyei Y" first="Yeboah" last="Marfo-Debrekyei">Yeboah Marfo-Debrekyei</name><name sortKey="Nurnberg, Peter" sort="Nurnberg, Peter" uniqKey="Nurnberg P" first="Peter" last="Nürnberg">Peter Nürnberg</name><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name><name sortKey="Toliat, Mohammad Reza" sort="Toliat, Mohammad Reza" uniqKey="Toliat M" first="Mohammad Reza" last="Toliat">Mohammad Reza Toliat</name></noCountry><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Debrah, Alexander Yaw" sort="Debrah, Alexander Yaw" uniqKey="Debrah A" first="Alexander Yaw" last="Debrah">Alexander Yaw Debrah</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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